Post - Reader
Cambridge University Address
Alison smith
Department of Plant Sciences
University of Cambridge
Downing Street, Cambridge.
CB2 3EA. United Kingdom.
Main research topics
Alison smith is interested in understanding the tetrapyrrole pathway and the synthesis of vitamins in higher plants. The tetrapyrrole pathway, which is responsible for the synthesis of chlorophyll, haem, sirohaem and phytochromobilin is regulated to ensure the coordination of apoprotein production. Vitamin B5 is the precursor of Coenzyme A; along with Chris Abell, Alison's group has solved the crystal structure of four E. coli enzymes. Her work involves the investigation into the relationship of CoA biosynthesis and its regulation.
Selected publications
Ottenhof, H.H., Ashurst, J.L., Whitney, H.M., Saldanha, S.A., Schmitzberger, F., Gweon, H.S., Blundell, TL., Abell, C. & Smith, A.G. (2004) Organisation of the pantothenate (vitamin 85) biosynthesis pathway in higher plants. Plant Journal 37:61-72.
Lobley, C. M. C., Schmitzberger, F., Kilkenny, M. L., Whitney, H. M., Ottenhof, H. H., Chakauya, E., Webb, M. E., Birch, L. M., Tuck, K. L., Abell, C., Smith, A. G. and Blundell, T. L. (2003) Structural insights into the evolution of the pan tothenate-biosynthesis pathway. Biochem. Soc. Trans. 31: 563-571.
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